A patented proprietary blend of anti-inflammatory Growth Factors, cytokines, and glycans, in the precise ratio, scientifically shown to accelerate healing and regenerate collagen, glucosaminoglycans, and elastin in connective tissue cells. Supplementing the correct level of specifically needed GFs induces repair of dermal tissue reversing visible signs of aging, reducing inflammation and restoring health within the skin. Our GFs deliver messages encouraging cell proliferation, differentiation, and healing, while cytokines deal with immune and inflammatory responses. 

Regenerative GF Complete is designed to deliver its patented combination of natural skin renewing GFs and cytokines to the deepest level of penetration and absorption triggering regeneration and repair at a molecular level in the skin. Unlike large collagen and elastin molecules which have difficulty penetrating, the specific Growth Factors and Cytokines selected for GF Complete create cell-to-cell signaling pathways which allow them to communicate deeply into the skin reaching the fibroblasts in the thick connective tissue of the dermis. They also posses the added advantage of penetrating mostly through vertical pathways such as the pore of hair follicles, sweat glands or micro lesions in the stratum corneum. So using GF Complete with penetrating procedures such as micro needling, micro dermabrasion, peels, and laser can further advance the acceleration of GF Complete healing agents. GF Complete has been designed with a unique delivery system of conditioned media enriched with phospholipids to further the absorption of GFs and Cytokines. GF Complete harnesses Glycosaminoglycans which stabilize GFs and act as super moisturizers to hydrate the dermal layer from within, penetrating where simple moisturizers cannot. As GF Complete’s regenerative blend penetrates, it enhances the immune response triggering secretion of additional vital growth factors necessary to stimulate cell repair, supplement the healing process, and increase the resilient volume of the extracellular matrix of the skin.

Images courtesy of Georgia Vadarli & Maria Angelo-Khattar, Plastic Surgery Consultancies, Greece & UAE. Additional images courtesy of Dr. Ahmed Al-Qahtani. 

Most topical products or treatments involve either: (1) damaging the skin causing trauma, which sends the skin into an inflammatory response in order to produce repair resources i.e. collagen and elastin; or (2) rely on hydrating ingredients, i.e. hyaluronic acid and glucosamine, to produce a temporary visible plumping of the skin, along with using  plant or animal based GF resources which produce an antioxidant affect, but don’t improve the molecular structure of human skin. This product was developed by immunologists who study the science of the body’s repair and prevention systems. Our immunologists understand through science that the bodies mechanism of successful skin healing and repair requires the cell to transition from the inflammatory stage to a granulation stage of repair and growth. Documented research shows the stimulation of fibroblasts occurs when specific levels and combinations of human GFs and Cytokines, in the appropriate delivery medium, signal the molecules required to induce healing and regeneration. Signs of aging reversal and skin repair is visibly apparent and longer lasting. Staying in recurring states of inflammatory response can be counteractive to the goal of healthy improvement. Intervention to reduce length and scale of inflammation is critical to sustained improvement and health. Regenerative GF Complete is ideal for individuals seeking non-surgical and less aggressive treatments with no-to-minimal downtime, but demand a high level of results. When combined with Regenerative GF Complete, patients surveyed express high levels of satisfaction with the treatment experience, less downtime and a feeling of more safety.

With Regenerative GF Complete application following CO2 laser procedures, the average healing time was reduce from 12 days to 6. Physicians reported seeing improved results over laser alone with significant collagen production, improved healing and shorter downtime. When used in conjunction with microneedling or peels, the advantages of applying GF Complete were: (1) no open wounds; (2) short duration of treatment; and (3) quick healing and recovery time with no to minimal downtime. They were also able to shorten the interval of treatment to 2 sessions vs 4 sessions and 2-3 weeks versus 4-6. However, the interval of 4-6 weeks should be respected based upon professional assessment and patient baseline condition.

PRP (Platelet Rich Plasma) was a breakthrough in the 1980’s as an original means of having a general source for human growth factors particularly for the purpose of potential bone healing. However, after many trials, PRP was not able to deliver consistent results and was moved to a more cosmetic use. In the three decades since that time, molecular biology and biotechnology has advanced the ability to understand the unique role of specific growth factors in producing certain healing resources and isolate those specific growth factors to create very targeted approaches to accelerate healing and repair. GF Complete leverages the biotechnology to sort specific GF types in the right ratio to get a very specific outcome for healing and rejuvenation. We can also control the “dose” or ratio of Growth Factor vs. PRP. For example, we use different growth factor complexes with different ratios in our retail product Wrinkle Reversing Serum designed for sustaining improved results at home versus GF Complete which is designed for more invasive skin damage to greatly reduce inflammatory response, enhance the healing and repair process. PRP in cosmetic use doesn’t have that same capability or the ability to stress fibroblasts in our skin to produce additional growth factors for continual improvement in the way GF Complete does. Most importantly GF Complete doesn’t require blood preparation which reduces concerns about contamination and spread of infectious disease.

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We named the professional product Regenerative GF Complete because it is the most complete skin care solution in terms of repairing the damage seen in the most widespread skin conditions while restoring healthy function of the cell for prevention and preservation. It clinically outperforms other skin care ingredient approaches:

Adipose Stem Cells.

Adipose or fat stem cells are easy to grow in lab, abundant and cheaper to produce. Adipose stem cells are commonly sourced from liposuction waste and have not been studied as thoroughly as fibroblasts.  Adipose stem cells perform endocrine functions in our body and secrete hormones into the bloodstream, which may have unintended effects on tissues. They are more highly inflammatory releasing several GFs which may disrupt healthy biochemical pathways in the body.  

Cell Lysates. 

Cell lysates are liquids that result from a process of breaking down cell membranes. Often controversial because they can be sourced from pre-embryonic sources including unfertilized human eggs or harvested from aborted fetal tissues. But the larger science concern is due to the treatment process which makes it hard to filter intact GFs.   

Animal Derived GF.

Many brands promote Animal Derived Growth factors such as sheep placenta, deer cord blood or snail slime. There is little published skin science other than that provided by manufacturers to support their use. There may be reaction concerns as these GFs are foreign to the human body. For example, snail mucosa especially causes inflammatory reactions. Plus, they cross-react with common household dust mites, putting you at risk for allergic reactions and other side effects. 

Plant Derivatives.

Plant-derived growth factors are botanicals which are commonly used ingredients in skin care. They can have anti-inflammatory and antioxidant properties and may also have antimicrobial components. Plant derivatives cannot achieve the same effect as human GFs because plant and human organisms speak a fundamentally different biological language. Human Growth factors work by communicating with cells and encouraging them to work in a specific way to rejuvenate function. 

Exosomes.

Although exosome-containing products are available in the marketplace, some companies that make them have received FDA warning letters. While Exosomes hold potential for helping to identify areas which may harbor cancer, there is no process for determining the quality, quantity or health condition of the Growth Factors contained within the Exosomes. FDA safety concerns could limit the commercial potential of exosome-containing skin care topicals for the near term.

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